Binding Leverage and Leverage Coupling as Determinants of Allosteric Regulation and Communication

Binding Leverage as a Molecular Basis for Allosteric Regulation

Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures the ability of a binding site to couple to the intrinsic motions of a protein. We use Monte Carlo simulations to generate potential binding sites and either normal modes or pairs...

Risk, Leverage, and Regulation of Financial Intermediaries

This paper presents a model on the leverage of …nancial intermediaries, where debt are held by risk averse agents and equity by the risk neutral. The paper shows that in an unregulated competitive market, …nancial intermediaries choose to be leveraged over the social best level. This is because the leverage of one intermediary imposes a negative externality upon others by reducing their pro…t m...

Bank Leverage Regulation and Macroeconomic Dynamics

Regulatory constraints on bank leverage have been at the center of many policy discussions recently. One important question to emerge from these discussions has been whether these regulations should be time-dependent and how they would interact with the business cycle. We analyze this question using a dynamic stochastic general equilibrium model with banks and bank capital. In the model, bank c...

8 Real Determinants of Corporate Leverage

Risk Sharing, (Over)Leverage, and Regulation

The paper examines the leverage of …nancial intermediaries in a general equilibrium framework. The paper’s approach is driven by risk sharing and captures two features: Debt serves to boost the return of equity and equity to "safe net" debt. The paper …nds that if entrepreneurs cannot obtain cheaper credit from …nancial intermediaries by reducing the investment scales, the equilibrium leverage ...